Recent Advances in the Synthesis and Pharmacological Profiling of Pyrazolo[1,5-a]pyrimidine Derivatives

Authors

Wesam S. Shehab, Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt AND Al-Farahidi University, Jadriya Bridge, P.O. 10011 Baghdad, IraqFollow
Seham Abdel-Shafi, Al-Farahidi University, Jadriya Bridge, P.O. 10011 Baghdad, Iraq AND Department of Botany and Microbiology, Faculty of Science, Zagazig University, Zagazig, 44519, EgyptFollow
Mostafa I. Abdelglil, Al-Farahidi University, Jadriya Bridge, P.O. 10011 Baghdad, IraqFollow
Sabry Shehata, Al-Farahidi University, Jadriya Bridge, P.O. 10011 Baghdad, Iraq AND Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig, 44519, EgyptFollow

Abstract

An important class of fused heterocyclic compounds, pyrazolo[1,5-a] pyrimidines have a variety of biological activities, such as anticancer, antimicrobial (antibacterial, antifungal, and antiviral), and enzyme-inhibitory effects. Additionally, it improves the body’s antioxidants and lowers the risk of diabetes. The synthesis and reactivity of distinct pyrazolopyrimidine derivatives using various cyclization and condensation techniques are the main topics of this study. To comprehend these compounds’ function in biological activity, their structural characteristics were thoroughly examined. The chemical pathways, reaction circumstances, and structural alterations that affect their pharmacological potential were highlighted. Pyrazolo[1,5-a] pyrimidines and their derivatives have potential uses in medicinal chemistry—particularly in the creation of novel therapeutic agents—are also highlighted in the study. The pyrimidines pyrazolo[1,5-a] exhibited antiviral properties against Newcastle disease.

Recommended Citation

Shehab, Wesam S.; Abdel-Shafi, Seham; Abdelglil, Mostafa I.; and Shehata, Sabry (2025) "Recent Advances in the Synthesis and Pharmacological Profiling of Pyrazolo[1,5-a]pyrimidine Derivatives," Al-Farahidi Biomedical Journal: Vol. 1: Iss. 1, Article 3.
Available at: https://fbmj.uoalfarahidi.edu.iq/journal/vol1/iss1/3